Abstract：The bitter gourd inbred lines ‘K7-359’（P1） and ‘K7-422’（P2）were taken as female and
male parents，respectively，to produce F1 and F2 populations．Major gene plus polygene mixed inheritance
model was used to perform genetic analysis for seed length，seed width and single seed weight of bitter gourd．
Results showed that the inheritance of seed length and single seed weight were consistent with the polygenic
genetic model with additive-dominant-epistasis effect（C-0 model）．The polygenic heritability were 84.91%
and 76.55%，respectively，indicating that selection of seed length and single seed weight should be carried out
in high generation．The inheritance of seed width was fitted to one pair of additive-dominant major gene plus
additive-dominant-epistasis polygene model（D-0 model）．The heritabilities of main gene and polygene were
79.30% and 3.86%，respectively，and genetic effect of major gene is mainly ascribed to the additive effect，
indicating combination breeding strategy could be used for genetic improvement of bitter gourd seed width，and
it was suitable to conduct selection on early generation．
