Field experiments were conducted to study the effects of nano zeolite（7 500 kg·hm-2）and ordinary zeolite（15 000 kg·hm-2）by different application methods（ broadcasting，furrowing，holing）on yield，quality and Cd content of Lactuca sativa L. and pH，CEC，total Cd and available Cd contents in soil．The results showed that the treatments of nano zeolite and ordinary zeolite all could significantly increase the yield of Lactuca sativa L. 131.5%-227.3% and 61.4%-196.0% higher than that of the CK，respectively．The highest yields was reached by broadcasting treatment．The plant contents of VC，amino acid and reducing sugar were increased and nitrate content was reduced．Furrowing treatment achieved the best effect in improving the quality of Lactuca sativa L．The Cd contents of plant above ground part were decreased by 11.3%-28.8% and 2.5%-16.7%，and the Cd contents in root system were reduced by 0.7%-26.8% and 9.9%-21.3%，respectively．Compared with the control，treatments of nano zeolite and ordinary zeolite reduced the soil available Cd content by 4.8%-19.0% and 9.5%-19.0%，respectively．Holing treatment of nano zeolite had the best effect in reducing Cd content in soil．While，furrowing treatment of ordinary zeolite had the best effect．Compared with the ordinary zeolite，nano zeolite treatment had a better effect in increasing yield of Lactuca sativa L.，decreasing nitrate content and Cd contents of plant above ground part．